Research Scientist, Evaluation, Valuation, Evaluation, Scientist, Research, Technology, Education

Department BSD NEU - Mastrianni Lab About the Department The Department of Neurology at The University of Chicago Medical Center has a great history and tradition, having made significant contributions to neurological training, clinical care, and the basic understanding of neurological disease. Job Summary The Research Scientist will support one of two projects in the laboratory, depending on the strengths and interests of the individual. An overarching goal of the lab is to define underlying molecular and cellular mechanisms responsible for distinct neurological disorders using a variety of in vitro and in vivo models. The knowledge gained from these studies will be applied to the development of therapeutic approaches. A current focus is the development and testing of an RNAi-based therapy for genetic forms of prion disease, which are neurodegenerative diseases due to the accumulation and propagation of misfolded prion protein (PrP). We have developed siRNAs that target only the mutated forms of PrP known to cause genetic prion disease in humans. We are currently using AAV vectors to deliver shRNA-encoding sequences to transgenic mice. The availability of a highly reliable genetic mouse model that was developed in our lab allows us to characterize the effects of this therapy on the well-characterized behavioral and histological phenotype of these mice. For this project, the Research Scientist will have demonstrated expertise in molecular and cell biological techniques across in vitro and in vivo systems that include, but are not limited to, molecular biological techniques required for the design, construction, and assessment of DNA sequences for expression of appropriate protein or RNA constructs, the application of PCR, RT-qPCR, western blotting and other forms of protein analysis, immunohistochemical staining of cultured cells and human and animal-derived histological samples. It is also critical that this individual has experience in the application of appropriate tools for the quantitative analysis of cellular and histological data. Direct experience with siRNA, viral vectors, and CRISPR would be a plus. Although the lab is primarily focused on prion diseases, there is also a significant effort directed at studying the role of PrP in Alzheimer’s Disease. We have uncovered a direct relationship between the expression of PrP and the generation and release of amyloid beta that forms the amyloid plaques of Alzheimer’s Disease. This relationship is present in cell lines that are stably transfected with normal or mutated amyloid precursor protein (APP), from which amyloid beta is generated. In addition, transgenic mice that express APP sequences are being bred with mice that express no, or high levels of PrP, to better study this relationship in vivo. Thus, in addition to having a strong background in the application of cellular and molecular biological techniques described above, experience in cell and/or animal models of Alzheimer’s Disease would be highly desirable for the candidate with an interest in this project. This at-will position is wholly or partially funded by contractual grant funding which is renewed under provisions set by the grantor of the contract. Employment will be contingent upon the continued receipt of these grant funds and satisfactory job performance. Responsibilities <ul><li>Perform basic scientific research using a variety of techniques and approaches to gain a better understanding of neurological conditions using in vitro cell-based systems and genetic mouse model systems. </li><li>Supervise Research Technician(s) that provide general technical support for all members of the laboratory. </li><li>Assist and provide technical and general scientific advice to other members of the laboratory. </li><li>Assist or lead in identifying and applying for sources of outside funding. </li><li>Assist in preparing manuscripts and presentations at meetings. </li><li>Recognize abnormal results and troubleshoot conditions or procedures to correct problems. </li><li>Adapt existing procedures to current work needs and make significant contributions to methodology. </li><li>Summarize results and assist in interpreting experimental findings. </li><li>Serves as a resource for collecting data and performing analysis. Facilitates and promotes a research project by providing scientific or intellectual information. </li><li>Develops laboratory protocols and training on new techniques. Manage, analyze and make recommendations on complex data sets for research. </li><li>Performs other related work as needed. </li> </ul> Minimum Qualifications Education: Minimum requirements include a PhD in related field. --- Work Experience: Minimum requirements include knowledge and skills developed through 5-7 years of work experience in a related job discipline. --- Preferred Qualifications Education: <ul><li>Doctoral degree in Biological Sciences or related field. </li> </ul>Experience: <ul><li>Broad knowledge and demonstrated experience with molecular and cell biological techniques, including manipulating DNA constructs, cell transfections, application of PCR, RT-qPCR, protein analysis, ELISA, and MSD, cell and tissue staining and quantification using ImageJ tools. </li><li>Experience in genetics, cell and tissue histological studies, application of immunohistochemical quantitation tools, and RNAi techniques (in vitro and in vivo). </li> </ul>Preferred Competencies <ul><li>Analytical skills. </li><li>Problem-solving. </li><li>Attention to detail. </li><li>Organizational skills. </li><li>Verbal and written communication skills. </li><li>Ability to work independently and as part of a team. </li><li>Demonstrated ability to publish first-author peer-reviewed papers. </li> </ul>Application Documents <ul><li>Resume/CV (required) </li><li>Cover Letter (required) </li> </ul>When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application. #J-18808-Ljbffr

Research Scientist (Metabolomics) page is loaded <h3>Research Scientist (Metabolomics) </h3> Apply locations Chicago, IL time type Full time posted on Posted 30+ Days Ago job requisition id JR27646 Department   BSD CCC - Metabolomics Platform About the Department   The University of Chicago Comprehensive Cancer Center (UCCCC) is an integral component of the Biological Sciences Division (BSD). The BSD is the largest of four Divisions of the University and includes the Pritzker School of Medicine. UCCCC administers four established scientific programs, and the NCI-sponsored Cancer Center Support Grant provides funding for ten Shared Resources. The Comprehensive Cancer Center is comprised of over 190 faculty members from twenty departments with members currently being awarded over $47 million in total direct costs in peer-reviewed cancer research grants, and $28 million in non-peer reviewed grants and contracts. The activities of the Center are broad and varied, including research, training and education, communications, fundraising, marketing, clinical trials management and community outreach. UCCCC has one of the largest cancer clinical trials programs in the country and in the Chicago area with nearly 500 adult and pediatric therapeutic trials actively accruing patients. Many of these studies are investigator-initiated, including Phase I or I/II trials, demonstrating UCCCC commitment to translate basic research findings to the clinic through proof-of-principle and early phase studies. UCCCC opens over 250 new trials each year and accrues approximately 900 participants to therapeutic trials each year Job Summary   Recently UCCCC has created a new metabolomics platform and it is part of a new BSD multi-omics facility. The Metabolomics Platform’s mission is to provide both: (1) cutting-edge metabolomics services and (2) expertise in metabolomics research development and experimental design to researchers in the Division, the University, and the Chicago area. We are seeking a research scientist to aid in the facility's advancement, establish metabolite profiling methods using state-of-the-art liquid chromatography-mass spectrometry systems, and perform routine metabolite sample preparation and analysis. Over time, research scientist will become experts in metabolite extraction from a wide variety of sample matrices, liquid chromatography-mass spectrometry (LC-MS) method development and troubleshooting, quantitative analysis of metabolites, stable isotope tracing, and metabolomics data analysis. We seek a Metabolomics -Research Scientist for the University of Chicago Comprehensive Cancer Center Metabolomics platform. This individual would directly report to the Metabolomics Platform Director and will have ample opportunity to grow and become an expert in metabolomics. The job performs routine assignments that facilitate and promote a research project or contributes to the scientific direction of a research resource. Receives instruction, guidance, and direction from others.Responsibilities <ul><li>Extracts metabolites from samples( cell culture, murine tissues, human biopsy and biofluids etc) and quantify concentration using LC-MS. </li><li>Analyzes mass spec/metabolomics data using specialized software programs (Tracefinder, Compound Discoverer, Skyline etc.). </li><li>Documents sample preparation, method development notes and data analysis results for the publication and reports. </li><li>Prepares mobile phases, stock solutions, troubleshoot process failures and participate in optimization of protocols. </li><li>Maintains inventory of lab supplies. </li><li>Interacts with students and other laboratory staff under the direction of the metabolomics platform director. </li><li>Aids the metabolomics platform director in advancing the technologies and managing day-to-day workflow. </li><li>Analyzes and maintains data and/or specimens. </li><li>Conducts literature reviews. </li><li>Participates in the preparation and writing of grant applications and reports, and co-authors/authors scientific research manuscripts. Provides peer review of grant applications and scientific manuscripts. </li><li>Collaborates on development of new research projects with academic and community-based organizations. </li><li>May present work at scientific meetings. </li><li>Performs other related work as needed. </li> </ul> Minimum Qualifications   Education: Minimum requirements include a PhD in related field.--- Work Experience: Minimum requirements include knowledge and skills developed through < 2 years of work experience in a related job discipline.--- Certifications: --- Preferred Qualifications Education: <ul><li>PhD in chemistry, analytical chemistry, biochemistry, chemical engineering or related field. </li> </ul>Experience: <ul><li>Hands on experience with basic chromatography and mass spectrometry techniques (GC-MS or LC-MS, LC-MS/MS) for small molecule analysis. </li><li>Experience working in a research laboratory or core facility. </li><li>Prior experience working with Thermo LC-MS instrument is a plus, but not required. </li><li>Proficiency in the use of computers and related software programs. </li> </ul>Working Conditions <ul><li>Ability to bend, crouch, or stoop. </li><li>Ability to lift loads up tp 49lbs. </li> </ul>Application Documents <ul><li>Resume (required) </li><li>Cover letter (preferred) </li> </ul> When applying, the document(s) MUST  be uploaded via the My Experience page, in the section titled Application Documents of the application. Job Family   Research Role Impact   Individual Contributor FLSA Status   Exempt Pay Frequency   Monthly Scheduled Weekly Hours   40 Benefits Eligible   Yes Drug Test Required   No Health Screen Required   Yes Motor Vehicle Record Inquiry Required   No Posting Statement   The University of Chicago is an Affirmative Action/Equal Opportunity/Disabled/Veterans and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender, gender identity, national or ethnic origin, age, status as an individual with a disability, military or veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination. Staff Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-5800 or submit a request via Applicant Inquiry Form. We seek a diverse pool of applicants who wish to join an academic community that places the highest value on rigorous inquiry and encourages a diversity of perspectives, experiences, groups of individuals, and ideas to inform and stimulate intellectual challenge, engagement, and exchange. All offers of employment are contingent upon a background check that includes a review of conviction history.A conviction does not automatically preclude University employment.Rather, the University considers conviction information on a case-by-case basis and assesses the nature of the offense, the circumstances surrounding it, the proximity in time of the conviction, and its relevance to the position. The University of Chicago's Annual Security & Fire Safety Report (Report) provides information about University offices and programs that provide safety support, crime and fire statistics, emergency response and communications plans, and other policies and information. The Report can be accessed online at:  . Paper copies of the Report are available, upon request, from the University of Chicago Police Department, 850 E. 61st Street, Chicago, IL 60637. <h3>Similar Jobs (5) </h3> <h3>Research Scientist, Metabolomics </h3> locations Chicago, IL time type Full time posted on Posted 7 Days Ago <h3>Research Scientist </h3> locations Chicago, IL time type Full time posted on Posted 17 Days Ago <h3>Research Professional, Analyst </h3> locations Chicago, IL time type Full time posted on Posted 30+ Days Ago #J-18808-Ljbffr

Research Scientist (Metabolomics) page is loaded    Research Scientist (Metabolomics)  Apply        locations  Chicago, IL       time type  Full time      posted on  Posted 30+ Days Ago      job requisition id  JR27646         Department

BSD CCC - Metabolomics Platform
About the Department

The University of Chicago Comprehensive Cancer Center (UCCCC) is an integral component of the Biological Sciences Division (BSD). The BSD is the largest of four Divisions of the University and includes the Pritzker School of Medicine. UCCCC administers four established scientific programs, and the NCI-sponsored Cancer Center Support Grant provides funding for ten Shared Resources. The Comprehensive Cancer Center is comprised of over 190 faculty members from twenty departments with members currently being awarded over $47 million in total direct costs in peer-reviewed cancer research grants, and $28 million in non-peer reviewed grants and contracts. The activities of the Center are broad and varied, including research, training and education, communications, fundraising, marketing, clinical trials management and community outreach.

UCCCC has one of the largest cancer clinical trials programs in the country and in the Chicago area with nearly 500 adult and pediatric therapeutic trials actively accruing patients. Many of these studies are  investigator-initiated,  including Phase I or I/II trials, demonstrating UCCCC commitment to translate basic research findings to the clinic through proof-of-principle and early phase studies. UCCCC opens over 250 new trials each year and accrues approximately 900 participants to therapeutic trials each year
Job Summary

Recently UCCCC has created a new metabolomics platform and it is part of a new BSD multi-omics facility. The Metabolomics Platform’s mission is to provide both: (1) cutting-edge metabolomics services and (2) expertise in metabolomics research development and experimental design to researchers in the Division, the University, and the Chicago area. We are seeking a research scientist to aid in the facility's advancement, establish metabolite profiling methods using state-of-the-art liquid chromatography-mass spectrometry systems, and perform routine metabolite sample preparation and analysis. Over time, research scientist will become experts in metabolite extraction from a wide variety of sample matrices, liquid chromatography-mass spectrometry (LC-MS) method development and troubleshooting, quantitative analysis of metabolites, stable isotope tracing, and metabolomics data analysis.

We seek a Metabolomics -Research Scientist for the University of Chicago Comprehensive Cancer Center Metabolomics platform. This individual would directly report to the Metabolomics Platform Director and will have ample opportunity to grow and become an expert in metabolomics.

The job performs routine assignments that facilitate and promote a research project or contributes to the scientific direction of a research resource. Receives instruction, guidance, and direction from others.   Responsibilities
Extracts metabolites from samples( cell culture, murine tissues, human biopsy and biofluids etc) and quantify concentration using LC-MS.

Analyzes mass spec/metabolomics data using specialized software programs (Tracefinder, Compound Discoverer, Skyline etc.).

Documents sample preparation, method development notes and data analysis results for the publication and reports.

Prepares mobile phases, stock solutions, troubleshoot process failures and participate in optimization of protocols.

Maintains inventory of lab supplies.

Interacts with students and other laboratory staff under the direction of the metabolomics platform director.

Aids the metabolomics platform director in advancing the technologies and managing day-to-day workflow.

Analyzes and maintains data and/or specimens.

Conducts literature reviews.

Participates in the preparation and writing of grant applications and reports, and co-authors/authors scientific research manuscripts. Provides peer review of grant applications and scientific manuscripts.

Collaborates on development of new research projects with academic and community-based organizations.

May present work at scientific meetings.

Performs other related work as needed.

Minimum Qualifications

Education:
Minimum requirements include a PhD in related field.  ---
Work Experience:
Minimum requirements include knowledge and skills developed through   ---
Certifications:
---
Preferred Qualifications
Education:
PhD in chemistry, analytical chemistry, biochemistry, chemical engineering or related field.

Experience:
Hands on experience with basic chromatography and mass spectrometry techniques (GC-MS or LC-MS, LC-MS/MS) for small molecule analysis.

Experience working in a research laboratory or core facility.

Prior experience working with Thermo LC-MS instrument is a plus, but not required.

Proficiency in the use of computers and related software programs.

Working Conditions
Ability to bend, crouch, or stoop.

Ability to lift loads up tp 49lbs.

Application Documents
Resume (required)

Cover letter (preferred)

When applying, the document(s)   MUST   be uploaded via the   My Experience   page, in the section titled   Application Documents   of the application.

Job Family

Research
Role Impact

Individual Contributor
FLSA Status

Exempt
Pay Frequency

Monthly
Scheduled     Weekly Hours

40
Benefits Eligible

Yes
Drug Test Required

No
Health Screen Required

Yes
Motor Vehicle Record Inquiry Required

No
Posting Statement

The University of Chicago is an Affirmative Action/Equal  Opportunity/Disabled/Veterans     and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender, gender identity, national or ethnic origin, age, status as an individual with a disability, military or veteran status, genetic information, or other protected classes under the law. For additional information please see the  University's Notice of Nondiscrimination.
Staff Job seekers in need of a reasonable accommodation to complete the application process should call  773-702-5800  or submit a request via  Applicant Inquiry Form.
We seek a diverse pool of applicants who wish to join an academic community that places the highest value on rigorous inquiry and encourages a diversity of perspectives, experiences, groups of individuals, and ideas to inform and stimulate intellectual challenge, engagement, and exchange.
All offers of employment are contingent upon a background check that includes a review of conviction history.A conviction does not automatically preclude University employment.Rather, the University considers conviction information on a case-by-case basis and assesses the nature of the offense, the circumstances surrounding it, the proximity in time of the conviction, and its relevance to the position.
The University of Chicago's Annual Security & Fire Safety Report (Report) provides information about University offices and programs that provide safety support, crime and fire statistics, emergency response and communications plans, and other policies and information. The Report can be accessed online at:      http://securityreport.uchicago.edu      . Paper copies of the Report are available, upon request, from the University of Chicago Police Department, 850 E. 61st Street, Chicago, IL 60637.
Similar Jobs (5)     Research Scientist, Metabolomics      locations  Chicago, IL      time type  Full time      posted on  Posted 7 Days Ago       Research Scientist      locations  Chicago, IL      time type  Full time      posted on  Posted 17 Days Ago       Research Professional, Analyst      locations  Chicago, IL      time type  Full time      posted on  Posted 30+ Days Ago

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